Category Archives: Leptin

Abdominal Fat First, Then Subcutaneous

Posted on June 30, 2013 by Robert Barrington

The ‘eat-too-much, do-too-little’ theory of obesity claims that weight loss is possible through forced calorie restriction and exercise. However, neither of these things treat the cause of obesity, and for this reason both are ineffective. Obesity is a metabolic disorder … Continue reading →

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Liquid Calories: Easier Weight Gain

Posted on June 26, 2013 by Robert Barrington

The digestive process in man is regulated by a hugely complex array of feedback mechanisms. One of the main feedback mechanisms that regulates digestion and subsequent metabolism is the satiety induced by certain food. Under normal circumstances, in a individual … Continue reading →

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Abdominal Adipose Tissue: Labile Store of Energy

Posted on June 22, 2013 by Robert Barrington

Obesity is associated with an increased risk of disease. In particular, obesity increases the risk of developing type 2 diabetes and cardiovascular disease. Obesity is characterised by excessive adipose tissue accumulation, and it is the metabolic changes that occur with … Continue reading →

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Sleep Deprivation and Obesity

Posted on June 11, 2013 by Robert Barrington

The purpose of sleep in humans and animals is not fully understood. However, during sleep certain restorative processes are thought to occur, and hormonal cascades are hypothesised to be part of this process. Sleep is therefore necessary for normal physiological … Continue reading →

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Sleep Stress: Obesity Trigger?

Posted on April 2, 2013 by Robert Barrington

Stress causes adaptation and allows beneficial changes to occur in organisms. For example, exercise is a form of stress that forces physiological adaptations to improve physical performance. However, following application of a stressor, time must be allowed for adaptation. During … Continue reading →

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Does Leptin Regulate Appetite?

Posted on February 4, 2013 by Robert Barrington

Leptin acts as a feedback signal to the hypothalamus to decrease appetite and increase metabolic rate as adipose tissue accumulates. Administration of leptin to ob/ob leptin deficient mice causes dramatic reductions in body weight. From these results it was hoped … Continue reading →

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Lack of Sleep Causes Increased Energy Intake

Posted on August 2, 2012 by Robert Barrington

The purpose of sleep is not fully understood, but it is thought to be an important period of restoration that is aided by hormonal changes. Research shows that adults who attain less than 7 hours of sleep a night have … Continue reading →

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Peptides that Regulate Feeding Behaviour: The anorectic Peptides

Posted on June 5, 2012 by Robert Barrington

Peptides that regulate appetite have been identified in the tissues of the gastrointestinal tract, pituitary, pancreas, hypothalamus and general neural tissues of mammals. These peptides tend to show paracrine, autocrine and endocrine functions that synergistically allows the regulation of energy … Continue reading →

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Is Obesity Really Caused by a Positive Energy balance?

Posted on June 2, 2012 by Robert Barrington

Obesity is a complex condition that involves the interaction of multiple genetic and environmental factors. Despite this complexity, the cause of obesity is often oversimplified to a condition of a positive energy balance. A small but consistent overconsumption of energy, … Continue reading →

Posted in Fructose, High Fructose Corn Syrup, Insulin Resistance, Leptin, Metabolic Syndrome, Obesity, Syndrome X, Weight Loss | Comments Off on Is Obesity Really Caused by a Positive Energy balance?

Associations with Leptin Levels

Posted on April 17, 2012 by Robert Barrington

Leptin is a peptide hormone that is involved in a negative feedback circuit to decrease appetite and increase energy expenditure in response to fat accumulation. Leptin is synthesised in adipocytes but binds to receptors in the hypothalamus where it stimulates … Continue reading →

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