Clark and Selenium, 1996

In 1996, Clark et al1 published the results from a double-blind placebo-controlled trial investigating the role of selenium supplements in cancer. In the study, 1312 subjects with a history of non-melanoma skin cancer were randomised to receive either 200 µg per day selenium yeast or a placebo. When the authors analysed the results they found that selenium had no significant effect on non-melanoma skin cancer rates. However, the group being administered the 200 µg per day selenium a had 50 % lower total mortality from cancer, a 37 % lower total cancer incidence, 63 % fewer cases of prostate cancer, 58 % fewer cases of colon cancer and 46 % fewer cases of lung cancer. Those subjects who experienced the greatest benefit from the selenium supplements were the ones in the lowest tertile for plasma selenium (<106 µg/L). Supplementation of this lowest tertile resulted in a 48 % reduction in the risk of cancer.

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1Clark, L. C., Combs, G. F., Turnbull, B. W., Slate, E. H., Chalker, D. K., Chow, J., Davis, L. S., Glover, R. A., Graham, G. F., Gross, E. G., Krongrad, A., Lesher, J. L., Park, K., Sanders, B. B., Smith, C. L., Taylor, R. 1996. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. Journal of the American Medical Association. 276: 19571985