Tocotrienols and Bone

Tocotrienols are a group of vitamers that have vitamin E activity. Along with the tocopherols, tocotrienols make up dietary vitamin E. Tocotrienols are antioxidants, and evidence suggests that they play a diverse role in human health. One aspect of the tocotrienols that has been well researched is that of prevention of male osteoporosis. Male osteoporosis is thought to relate to the deficiency of testosterone that occurs with ageing, and which can be a significant cause of bone fractures. Tocotrienols have been shown to reduce the risk of male osteoporosis and many animal models have been used to explain the mechanism of this finding. For example, tocotrienols were able to increase osteoblast number. Improve bone formation, improve mineral deposition, and improve bone microarchitecture in rats. Overall, this improved bone mineral density. The authors suggested that the improvements may have derived from the antioxidant, anti-inflammatory or gene regulatory role of vitamin E. 

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Chin, K.Y. and Ima-Nirwana, S. 2015. The biological effects of tocotrienol on bone: A review on evidence from rodent models. Drug Design, Development and Therapy. 9: 2049

About Robert Barrington

Robert Barrington is a writer, nutritionist, lecturer and philosopher.
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