D-aspartic acid is an amino acid found in the mammalian central nervous system. Evidence suggests that D-Aspartic acid may be involved in the synthesis and release of testosterone. D-aspartate is not essential and is synthesised in cells naturally. The amino acid is found throughout the brain, but is localised in certain areas particularly the axon terminals and synaptic vesicles, which suggests it acts as an important neurotransmitter. In the endocrine system, D-Aspartic acid may be involved in the function of the pineal gland, the pituitary gland, the adrenal gland and the testis. Evidence suggests that D-aspartic acid may play a role in the synthesis and release of hormones. D-aspartic acid may induce prolactin release in the anterior pituitary, modulate oxytocin and vasopressin in the posterior pituitary, suppress melatonin synthesis from the pineal gland and modulate steroid synthesis in the adrenal gland. In animal studies administration of D-aspartate consistently stimulates testosterone secretion.
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