Resveratrol as a PPAR Ligand: Mood Stabiliser

Resveratrol is a polyphenol present in the skin of red grapes. As a result one of the best dietary sources of resveratrol is red wine. Other food sources of resveratrol include pomegranate and nuts. Resveratrol has been evidenced to exert beneficial effects on mental health. This may relate to the evidence that shows that resveratrol is able to reduce neuronal inflammation in the hippocampus, and this may have a beneficial effect on mood. In particular, resveratrol has been shown to improve symptoms of depression and anxiety. The mechanism for this is not fully understood, but evidence suggests that resveratrol can activate PPAR (peroxisome proliferator-activated receptor) in brain tissue. The stimulation of PPAR by resveratrol may activate the PPAR-steroidal axis, which results in the release of allopregnanolone into the brain, and this provides significant anti-inflammatory effects within brain tissue. As inflammation is associated with low mood, resveratrol may be highly protective in this regard. 

Eat Well, Stay Healthy, Protect Yourself


Matrisciano, F. and Pinna, G. 2020. PPAR and functional foods: Rationale for natural neurosteroid-based interventions for postpartum depression. Neurobiology of Stress. 12: 100222

About Robert Barrington

Robert Barrington is a writer, nutritionist, lecturer and philosopher.
This entry was posted in Anxiety, Depression, Mood, Resveratrol. Bookmark the permalink.