Lamiophlomis rotata is a Tibetan herb that is sometimes commonly called Kudo. The herb is traditionally used to treat pain which suggests that it may have activity on the central nervous system. The active ingredients in Lamiophlomis rotata are iridoid glycosides including mainly shanzhiside methylester (SM) and 8-O-acetyl-SM (8-OaS). Some evidence suggests that these iridoid glycosides may have neuroprotective effects which may make them effective treatments for mood disorders. The pain relieving (nociceptive) effects of 8-O-acetyl-SM targets the spinal cord’s neuroinflammatory response. Studies investigating the effects of 8-O-acetyl-SM on animals models of anxiety demonstrate that the compound has significant anxiolytic effects. Mechanistically this may relate to regulation of the excitability of certain parts of the brain through modulation of the GABA neurotransmission system and a regulation of inflammatory responses in the basolateral amygdala (part of the brain tasked with conditioning).
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