Resveratrol: Anti-Anxiety Component of Red Wine?

Red wine is a complex mixture of phytochemicals and their metabolites. One phytochemical in red wine is resveratrol, a polyphenol antioxidant that is found in grapes. Evidence suggests that resveratrol is effective at protecting from a number of diseases, and may improve both physical and mental health. Evidence suggests that resveratrol is protective of mood disorders, and this may relate to its antioxidant capacity. For example, in one study, researchers administered resveratrol to rats and exposed the rats to experimental stress. Both in an acute and chronic administration pattern, resveratrol was effective at reducing the depressive-like behaviour of the rats in the forced swimming test. This improvement in mood was facilitated without any detrimental effects on locomotor activity, suggesting it was not due to sedation. In addition, the levels of brain derived neurotrophic factor were elevated in the hippocampus area of the brains of the rats, suggesting the resveratrol had neuroprotective effects.

red wine anxiety depression mood

Resveratrol, chemically 3,4’,5-trihydroxy-trans-stilbene, is a natural non-flavonoid polyphenol antioxidant that is found in red grapes and transferred to red wine during processing. In animals models, resveratrol may reduce depressive behaviour following the application of stress.

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Hurley, L. L., Akinfiresoye, L., Kalejaiye, O. and Tizabi, Y. 2014. Antidepressant effects of resveratrol in an animal model of depression. Behavioural Brain Research. 268: 1-7

About Robert Barrington

Robert Barrington is a writer, nutritionist, lecturer and philosopher.
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