Iron is an essential element required for neurotransmitter synthesis and cell function. Iron is important in the oxygenation of cells , and plays role in oxygenation of the brain, enzymes and neurotransmitters. Proper iron status is therefore pivotal to correct mental function. Iron is able to interact with the N-methyl-D-aspartate (NMDA) receptor as iron forms part of the iron responsive-element binding protein (IRE-BP). This protein is required for post transcriptional RNA synthesis following activation of the NMDA receptor by nitric oxide. This may explains the association between iron and mental health. Despite this, some confusion remains about the role of iron in depression because it has been suggested that low iron status may result from depression, rather than be the cause of it. However, it is clear that iron deficiency may be a causative factor in mental deterioration and modifications to normal behaviour, and so a diet low in iron is likely to exacerbate any potential causes of a mood disorder.
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