Galphimia glauca is a flowering plant from the Malpighiaceae family of plants. Galphimia glauca is used in Mexico as a traditional medicine as a mild sedative or tranquiliser. Galphimia glauca has been shown to have anxiolytic effects in animals and humans. The effects of Galphimia glauca is thought to be due to the presence of active constituents called galphimines. Galphimines are nor-seco-terpenes, with 30 carbons arranged in 5 rings with particular central nervous system effects. Evidence for this comes from animals studies showing anxiolytic effects from isolated galphamines. In comparison studies, galphamines have been shown to be as effective a the benzodiazepine drug diazepam in animals. In humans, comparison studies show the anxiolytic effects are similar to that seen for the benzodiazepine drug lorazepam. Galphamines therefore appear to be an effective treatment for individuals with mild to moderate anxiety such as found in the generalised anxiety disorder (GAD).
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