Doxycycline is an antibiotic often used to treat acne and respiratory tract infections. Side effects from the drug are known to include hepatotoxicity, pancreatitis, blood disorders, photosensitivity, hypersensitivity reactions, headache and visual disturbances. A number of medical case studies have been performed on young subjects who were treated for various skin disorders with doxycycline. However, this treatment subsequently caused suicidal feelings within the individuals. Further investigation revealed that the siblings of one of the individuals in the case study had also developed severe anxiety when being treated with doxycycline. These mood disorders all resolved themselves after removal of the doxycycline treatment suggesting that the drug had reversibly disrupted the brain chemistry of the individuals. The authors of the research paper that reported these findings, suggest that a genetic susceptibility to doxycycline may be present in certain individuals, such that these individual are not able to properly metabolise and excrete the drug because they have a defect in the relevant cytochrome metabolising enzyme.
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