Category Archives: Gamma Linolenic Acid

Plasma Fatty Acids of Alaskan Eskimos

Native inhabitants of northern parts of Canada, Alaska and Greenland rely on marine sources for their protein and energy needs. These food sources tend to include both marine mammals and cold water fish that contain high levels of long-chain polyunsaturated … Continue reading

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Imbalances in Essential Fatty Acids

The essential fatty acids (EFAs) linoleic acid (LA, C18:2 (n-6)) and α-linolenic acid (ALA, C18:3 (n-3)) can be metabolised to other more unsaturated, long-chain fatty acids by the insertion of additional double bonds during consecutive elongation and desaturation reactions. The … Continue reading

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Essential Fatty Acids in Early Development

The two essential fatty acids (EFA), linoleic acid (LA, C18:2 (n-6)) and α-linolenic acid (ALA, C18:3 (n-3)), are required in the diet because humans are unable to synthesise them de novo. A series of elongation and desaturation reactions creates a … Continue reading

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GLA and Weight Control

The essential fatty acids α-linolenic acid (ALA, C18:3 (n-3)) and linoleic acid (LA, C18:2 (n-6)) and their metabolites play an important role in human health. Metabolism of ALA and LA produces a range of pro- and anti-inflammatory eicosanoids, and the … Continue reading

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Polyunsaturated Fatty Acids and PPAR

The peroxisome proliferator-activated receptor (PPAR) family are ligand-activated nuclear transcription factors involved in the regulation of lipid metabolism through gene expression of peroxisome number. It is thought that the PPAR are activated by C18 to C22 n-3 and n-6 fatty … Continue reading

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GLA and EPA Interaction

Starflower (borage) and evening primrose oils are good sources of the n-6 long chain polyunsaturated fatty acid γ-linolenic acid (GLA, C18:3 (n-6)). In humans GLA is converted to dihomo-γ-linolenic acid (DGLA, C20:3 (n-6)) which is subsequently converted to the anti-inflammatory … Continue reading

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More on GLA and Inflammation

The essential fatty acids α-linolenic acid (ALA, C18 (n-3)) and linoleic acid (LA, C18:2 (n-6)) play an important role in the formation of eicosanoids. Eicosanoids are 20-carbon chemicals that act as local hormones to regulate cellular inflammation. Eicosanoids can be … Continue reading

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Important Long Chain Fatty Acids

There are a number of long chain fatty acids that are important to human health (figure 1). The essential fatty acids alpha-linolenic (ALA, C18:3 (n-3)) acid and linoleic acid (LA, C18:2 (n-6)) cannot be synthesised by humans but are vital … Continue reading

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Essential Fatty Acids in Skin

Skin conditions are associated with n-6 fatty acids but generally not with n-3 fatty acid. The result of n-6 deficiency is increased inflammation, which includes heat, pain, redness, swelling, and loss of function. This can cause weeping, increased proliferation of … Continue reading

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Fatty Acids, Eicosanoids and Arachidonic Acid

Alpha linolenic acid (ALA) and linoleic acid (LA) are polyunsaturated fatty acids (PUFA) of the omega 3 and 6 family respectively, and are both essential to health. These fatty acids have a number of important function in humans, and deficiency … Continue reading

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