Category Archives: Fatty Acids

De Novo Lipogensis and Insulin Resistance

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Saturated Fat and Health

The role of saturated fat in health has been distorted from the original observations within the scientific literature. Saturated fat has been implicated as a disease causing agent, and this is really at odds with the data from peer review … Continue reading

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How Do Almonds Make Healthy Rats?

Nut have been extensively investigated for their health effects in both humans and animals. Evidence suggest that consumption of nuts has a number of protective effects against disease. In particular nuts appear to have protective effects against cardiovascular disease. However, … Continue reading

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High Protein Diets Lower Liver Fat

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The Insulin Sensitivity Paradox

Insulin sensitivity describes the efficiency of cells to transport extracellular glucose across their cell membranes to the interior of the cell. This glucose is then used as a source of energy in respiration, or to synthesise other compounds for storage. … Continue reading

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Caffeine and Insulin Sensitivity

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Fat Intolerance and Inflammation

The metabolic syndrome is a cluster of metabolic dysfunctions characterised by central and peripheral insulin resistance. Insulin resistance is a condition whereby the cells of the body become insensitive to the action of insulin and as a result less of … Continue reading

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Malonyl-CoA: Pivotal In Insulin Resistance?

Malonyl-CoA is an intermediate in the de novo synthesis of fatty acids. Stimulation of the de novo lipogenesis pathway therefore increases the production of malonyl-CoA. Malonyl-CoA is an important intermediate in this pathway because it allosterically inhibits a number of … Continue reading

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Acetyl L-Carnitine Improves Glucose Control

L-carnitine is a non-essential nonproteinaceous amino acid in human nutrition. L-carnitine is manufactured in humans, but can be ingested in the diet, with good sources being animal flesh. L-carnitine is involved in the transport of long chain fatty acids into … Continue reading

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Free Fatty acids and Insulin Resistance

Insulin resistance is thought to be a primary contributory factor in the development of obesity. Evidence supports the contention that increased accumulation of free fatty acids in tissues, as typified by elevated blood levels, are a significant contributory cause of … Continue reading

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