Cannabis sativa is perhaps most well known for the psychoactive phytochemical Δ9-tetrahydrocannabinol. However, Cannabis sativa contains a large number of cannabinoids and most are not psychoactive. Evidence suggests that cannabidiol, one of the cannabinoids in Cannabis sativa, has anti-anxiety effects in animals. For example, in healthy subjects cannabidiol is able to block the anxiety normally caused by administration of Δ9-tetrahydrocannabinol. Many studies have also reported that cannabidiol is able to exert an anti-anxiety effect in animal models of anxiety. In humans, some studies have shown that cannabidiol is able to reduce anxiety in humans with clinically diagnosed anxiety disorders. In particular, panic disorder, obsessive-compulsive disorder, social anxiety disorder, and post-traumatic stress disorders appear to respond positively to cannabidiol administration. Cannabidiol is available is purified form such that it can be taken orally without the associated Δ9-tetrahydrocannabinol.
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