Daily Archives: December 7, 2012

Biotin and Leucine Metabolism

Conversion of 3-methylcrotonyl CoA to 3-methylglutaconyl CoA is a metabolic step in leucine catabolism pathway that is catalysed by the enzyme methylglutaconyl CoA carboxylase (MCC). Biotin is required as a cofactor for the MCC enzyme, and marginal biotin deficiency reduces … Continue reading

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